Jordi Alastruey, PhD
Senior Lecturer
Department of Biomedical Engineering
3rd floor Lambeth Wing
St Thomas' Hospital
SE1 7EH London
United Kingdom
Research
In my lab we study blood flow in the cardiovascular system using in vivo data and experimental, numerical and theoretical models. We investigate and develop methods to improve diagnosis and monitoring of cardiovascular function by analysis of arterial pulse wave signals. For example, in collaboration with medical doctors, biologists, mathematicians and other biomedical engineers, we are (i) developing a non-invasive method to calculate blood pressure in the aorta using patient-specific mathematical models and clinical imaging (Am J Phys, 2015); (ii) researching techniques for measuring the stiffness of the aortic wall, which is an important marker of vascular health (JCMR, 2017; Am J Phys, 2015, Ann Biomed Eng, 2013; J Biomech, 2011); and (iii) studying the relative contribution of physical properties of the heart, aorta and peripheral vessels towards increasing arterial blood pressure with hypertension (Ann Biomed Eng, 2014; Hypertension, 2017, 2014 & 2012). These and other projects are described here.

An important computational tool for this research is our in-house code Nektar1D, which I started developing during my PhD. Nektar1D simulates arterial blood pressure, flow and luminal area waves in networks of compliant vessels using the nonlinear, one-dimensional (1D) formulation. Nektar1D has allowed us to show that fast and accurate calculation of arterial pulse waveforms in the aorta and other large arteries is feasible on a standard PC. 1D modelling provides a good balance between accuracy and computational cost, as demonstrated by comparison against experimental data in a 1:1 scale model of the systemic circulation made of silicone tubes (J Biomech, 2011 & 2007), in vivo data in humans (J Royal Soc Interface, 2016), and 3D numerical data in compliant vessels (Int J Numer Meth Biomed Engng, 2015 & 2014). We have recently used Nektar1D to create populations of thousands of virtual subjects for investigating and developing cardiovascular indices calculated from pulse waveforms (J Biomech, 2016; Am J Phys, 2015).

A complete list of my journal papers can be found below. For Google Scholar click here and for ResearchGate here.
Employment and Education
09/2017 - now
Senior Lecturer at King's College London, UK
Division of Imaging Sciences and Biomedical Engineering
11/2013 - 08/2017
Lecturer at King's College London, UK
Division of Imaging Sciences and Biomedical Engineering
08/2006 - 10/2013
British Heart Foundation (BHF) Research Fellow at Imperial College London (Department of Bioengineering) and King's College London (Department of Biomedical Engineering)
Experimental and numerical modelling of blood flow in the cardiovascular system to improve our understanding of hypertension
07/2006 - 10/2009
Post-doctoral Research Associate at Imperial College London, UK, Departments of Aeronautics and Bioengineering
Experimental and numerical modelling of blood flow in the cardiovascular system with application to cerebral haemodynamics
02/2003 - 07/2006
PhD Thesis in Biomedical Engineering at Imperial College London, UK, Departments of Aeronautics and Bioengineering
1996 - 2002
BS and MS in Civil Engineering
Universitat Politècnica de Catalunya (UPC)
Publications