Jorge Aramburu
Visiting researcher
jaramburu@tecnun.es
5th floor Becket House
SE1 7EH London
United Kingdom
Research
During his stay at HaeMod, Jorge's research will be focused on developing a computer model of the Fontan circulation, i.e. the cardiovascular system of patients that were born with a single functional ventricle and undergone the Fontan operation. Before the operation, the oxygenated blood carried by the pulmonary veins and the deoxygenated blood carried by the systemic veins get mixed in the heart. The main problem with these patients is the hypoxemia (i.e. low levels of oxygen in the blood). To solve this problem, the Fontan operation is performed. This operation consists of connecting the inferior vena cava and the superior vena cava to the pulmonary arteries, so that blood flows directly to the lungs without flowing through the heart. The figure below shows an example of the circulation of a patient with tricuspid atresia (absence of tricuspid valve), atrial septal defect (no wall between right and left atria, RA and LA) and ventricular septal defect (no wall between right and left ventricles, RV and LV), before and after the Fontan operation. Before the operation, the oxygen saturation is not sufficiently high in the systemic arteries and the pulmonary veins nor sufficiently low in the systemic veins and pulmonary arteries. After the operation, normal-circulation-like oxygen saturation levels can be achieved.

The parameters of the model will be estimated using the pressure (P) and blood-flow (Q) measurements at different locations of the circulation, performed by the physicians at Guy's and St Thomas' NHS Foundation Trust. Then, different actions will be simulated in the model and its effect on the cardiovascular system will be analysed.

In his PhD, he analysed the influence of modifying some parameters in liver radioembolisation via numerical studies. Liver radioembolisation is a treatment for liver cancer and consist of the catheter-based intra-arterial injection of radiation-emitting microspheres to locally attack the tumours. In the studies, the three-dimensional particle–haemodynamics were numerically analysed in a patient-specific hepatic artery under literature-based cancer scenarios.
As an example of the studies carried out, the videos below show how a 5-mm longitudinal shift in the catheter tip influences the particle distribution in the lobes of the liver. In the first video, the green particles only go to the right lobe. In the second, the red particles treat both the right and the left lobes. The only different between the simulations is a 5-mm longitudinal shift in the catheter tip.
After his stay at King's College London, he will return to his job as a lecturer and researcher at TECNUN Escuela de Ingenieros, the School of Engineering of Universidad de Navarra.
Experience and Education
1/2018 - now
Visiting researcher at King's College London, London, UK
Department of Biomedical Engineering
Mathematical modelling of the cardiovascular system of patients with Fontan heart.
09/2017 - now
Ayudante Doctor at Universidad de Navarra, Donostia-San Sebastián, Spain
Department of Mechanical Engineering and Materials
Lecturer and researher of the Thermal and Fluids Engineering Division
01/2017 - 09/2017
Researcher at Universidad de Navarra, Donostia-San Sebastián, Spain
Department of Mechanical Engineering and Materials
Lecturer and researcher of the Thermal and Fluids Engineering Division
01/2013 - 12/2016
PhD student, PhD in Applied Engineering at Universidad de Navarra, Donostia-San Sebastián, Spain
Department of Mechanical Engineering and Materials
Thesis: Liver radioembolization: Computational particle–hemodynamics studies in a patient-specific hepatic artery under literature-based cancer scenarios
Supervisor: Dr. Raúl Antón
2012/2013
Master student, Master in Research in Applied Engineering at Universidad de Navarra, Donostia-San Sebastián, Spain
Thesis: A novel methodology for measuring local changes in the shape of vessels and its application to the intraluminal thrombus growth in an abdominal aortic aneurysm
Supervisor: Dr. Raúl Antón
2007/2008 - 2012/2013
Engineering student, Industrial Engineering at Universidad de Navarra, Donostia-San Sebastián, Spain
Thesis: A numerical analysis of hemodynamic parameters during the growth of an abdominal aortic aneurysm
Supervisor: Dr. Raúl Antón
2007/2008 - 2012/2013
Engineering student, Automatic and Electronic Systems Engineering at Universidad de Navarra, Donostia-San Sebastián, Spain
Thesis: Dynamic estimation of the fouling in a membrane bioreactor via the extended Kalman filter
Supervisor: Dr. Sergio Beltrán
Publications
Links