During his time at HaeMod, Jorge developed a patient-specific, closed-loop computational model of the Fontan circulation for single-ventricle patients (Heliyon, 2024). Using one-dimensional models for major vessels (aorta, venae cavae, pulmonary arteries) and zero-dimensional models for heart chambers and smaller vessels, the model simulated pulsatile blood flow. It was calibrated using haemodynamic data from cardiac catheterisation and MRI via a novel physics-based, stepwise approach with simpler open-loop models.

Testing on a 10-year-old anesthetised patient showed the model accurately reproduced pulsatile pressure and flow, with mean pressure and flow errors of 2.9% and 3.6%, and relative point-to-point errors (RPPE) of 5.2% and 16.0%. Ventricular pressure and volume were also closely matched, with RPPE of 2.9%. The model predicted realistic haemodynamic effects from pulmonary vasodilation and atrial fenestration.
The model and calibration method are open-source, supporting virtual testing of clinical interventions and investigations into Fontan failure. Future work aims to expand its clinical applicability.

For his PhD, Jorge studied liver radioembolisation - a catheter-based treatment for live cancer using radiation-emitting microspheres to locally attack tumours. He numerically analysed three-dimensional particle–haemodynamics in a patient-specific hepatic artery under various tumour scenarios. As an example of the studies carried out, the videos below show that a 5-mm longitudinal shift in catheter tip altered particle distribution in the lobes of the liver. In the first video, green particles targeted only the right lobe. In the second, red particles reached both lobes. The only different was the catheter tip position.

Jorge is currenlty a lecturer and researcher at TECNUN Escuela de Ingenieros, the School of Engineering of Universidad de Navarra.