Samuel Vennin
Biomechanical Engineer
samuel.vennin@kcl.ac.uk
5th floor Beckett House
SE1 7EH London
United Kingdom
Research
Sam's research focuses on developing novel haemodynamic measurement technologies by investigating the relationship between aortic central blood flow (Q), and pressure (P) through the parameters that link them such as peripheral resistance (R), total compliance (C) and pulse wave velocity (PWV).

To address current methodologies shortcomings, Sam uses a unique mix of numerical and clinical data for establishing proofs of concept for protocols that are subsequently validated in clinical settings. This approach also allows to investigate the haemodynamic mechanisms at play in cardiovascular diseases.
During his PhD, he tackled the following challenges:
  1. Aortic pressure can hardly be acquired during MRI scanning while this is the preferred imaging modality to assess cardiac anatomy and mechanics. Sam developed an innovative protocol to obtain the central blood pressure waveform from MRI-acquired aortic flow waveform (Am J Phys, 2015 ; J Biomech, 2016).
  2. Haemodynamic mechanisms behind pulse pressure increase in hypertension are still disputed. Validation of a three-element Windkessel with in silico and in vivo data enabled to identify and separate the main arterial and cardiac determinants to elevated pressure: total arterial compliance dominates in determining the contribution of arterial tree, while ventricular dynamics account for a relatively large proportion of the increased pulse pressure in hypertesion (Hypertension, 2017).
  3. Continuous monitoring of cardiac output requires specialist equipment and invasive access while non-invasive alternatives does not provide accurate estimates of beat-to-beat variations despite the value such information would have in intensive care units. A protocol to estimate within-patient variations in cardiac output from non-invasive and readily available measurements of aortic pressure and pulse wave velocity has been developed.
Now as a Biomechanical Engineer Research Fellow, Sam is working on the clinical translation of his protocols.
Experience and Education
12/2017 - now
Biomechanical Engineer Research Fellow at King's College London, London, UK
Department of Clinical Pharmacology
Clinical translation of new haemodynamic measurement methodologies
10/2014 - now
PhD Thesis in Cardiovascular Sciences at King's College London, London, UK
British Heart Foundation Centre of Research Excellence, Department of Clinical Pharmacology
Thesis: An integrated in silico and in vivo approach to understanding the relationship between central blood pressure and flow; with applications for non invasive haemodynamic measurement technology
Supervisors: Prof. Phil Chowienczyk, Dr Jordi Alastruey
09/2013 - 09/2014
Master in Biomedical Engineering at Imperial College London, London, UK
Noninvasive Surgery & Biopsy Laboratory, Department of Bioengineering
Joint degree with ENSEA
Thesis: Noninvasive palpation using microbubbles and ultrasound
Supervisor: Dr James J. Choi
09/2011 - 09/2014
Master in Electrical Engineering at Ecole Nationale Superieure de l'Electronique et de ses Applications (ENSEA), Cergy, France
French engineering degree
Publications
Links